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Kit VitiDerm® Topical gel + Softgels

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Vitiligo is characterized by a catalase deficiency that leads to the vacuolization of the melanocytes and keratinocytes.

VitiDerm® is an innovative product from DermoPro.

Oxidative stress and depigmentation

Due to oxidative stress (high concentrations of free radicals) vacuolization and cell death occur.

These include a gradual loss of melanocytes(1)(2)(3)(4) and an abnormally high level of hydrogen peroxide (H2O2) in the epidermis, leading to oxidative stress and oxidation of proteins and lipids.(5)

Keratinocytes in vitiligo lesions have proinflammatory responses, which can be inhibited through the combination of SOD and Catalase.

Concentration of hydrogen peroxide (H2O2) in vitiligo patients

 
Concentration of hydrogen peroxide (H2O2) in patients with vitiligo (red) compared to patients without vitiligo (blue)(9)

Numerous recent studies have pinpointed certain anomalies in patients with skin depigmentation.

In patients with vitiligo, it has been shown that a deficiency in catalase, vitamins and minerals is one of the causes of oxidative stress.(7) (12).

Oxidative stress damages the melanocyte membranes, the cells which are essential for skin pigmentation (6).

Cell damage in patients with vitiligo

Cell damage in vitiligo patients (red) and control subjects (blue) exposed to an increasing concentration of H2O2 (from 1-100 mM). Oxidative stress level and tyrosinase activity in vitiligo patients(8)

Restoring the physiological conditions for pigmentation :

- Melon extract : Superoxede dismutase - SOD and catalase
- Ginkgo Biloba : Prevent cells from oxydative stress like melon
- Selenium : Contributes to a normal immune system and to protect cells from oxidative stress
- Vitamins C : Contributes to a normal immune system and to protect cells from oxidative stress
- Vitamins A : Metabolism of iron (important to vehicule oxygen), protection of DNA, proteins and lipids from oxidative damage maintenance of normal skin, maintenance of the normal function of the immune system
- Vitamin E : Contributes to protect cells from oxidative stress, maintenance of the normal function of the immune system, protection of DNA, proteins and lipids from oxidative damage, maintenance of normal skin, regeneration of the reduced form of vitamin C
- Silica : Enable a normal development of the conective tissue
- Ascorbyl palmitate : Contribution to normal energy-yielding metabolism
- Acerola : Protect DNA and prevent cells from oxidative stress (80 more powerfull than vitamin C) Green tea, calcium carbonate

Ingredients : Aqua, Propylene glycol, Alcohol denat, PEG-40 Hydrogenated Castor Oil, Ginkgo Biloba Extract, Cucumis Melo Fruit Extract, Calcium Chloride, Glycerin, Ethylhexylglycerin, Sodium Hydroxide, Citric Acid, Parfum, Benzyl alcohol, Potassium Sorbate, Sodium benzoate.

VitiDerm in farmacy : Available from dispensing chemists:

ACL 9968447 or order from our laboratoires throught this page

Bibliography and scientific references :

1/ Disruption of phénylalanime hydroxylase in a cycle dysfonctionement biopterin / 6-BH4. Epidermal H2O2 accumulation alters the cycle of tetrahydrobiopterin (6-BH4) of known importance in the early stages of melanin synthesis and catecholamine which are accompanied by a lowering of catalase.
Calcium intake and catalase reduces the levels of H2O2 and regulates the cycle of biopterin.
2/ Tyrosinase is the key enzyme of melanogenesis responsible for pigmentationIt loses its effectiveness in the presence of oxygen free radicals (superoxide ion O2-). The contribution of catalase and SODGinkgo Biloba can reduce levels of O2-H2O2
3/Melanin bleached in the presence of oxygen radicals (OH).
A contribution of catalase and SODGinkgo Biloba can reduce levels .OH

(A) Karin U Schallreuter*,†, Jeremy Moore*, John M Wood*, Wayne D Beazley*, Eva M J Peters*, Lee K Marles*, Stefanie C Behrens-Williams*, Reinhard Dummer‡, Nenad Blau§ and Beat Thöny§
1.*Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, U.K
2.†Institute for Pigmentary Disorders e.V. in Association with the Ernst-Moritz-Arndt University Greifswald, Germany
3.‡Department of Dermatology, University Hospital, Zurich, Switzerland
§Division of Clinical Chemistry and Biochemistry, University Children's Hospital, Zurich, Switzerland.
(B) DRS DUGAS B, SIVAS V, FRANCES C, DEBRE P, Effet protecteur de l'association des Superoxydes Dismutases et de la Catalase végétales sur le développement inflammatoire associé au vitiligo chez l'homme.
(C) Successful treatment of oxidative stress in vitiligo. Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford. Schallreuter KU. Skin Pharmacol Appl Skin Physiol. 1999 May-Jun;12(3):132-8 

100 ml tube Non-greasy, paraben-free gel.

Gel : To be applied morning and evening. Massage into clean, dry skin using light strokes.
Softgels : 3 per day

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Kit VitiDerm® Topical gel + Softgels

Kit VitiDerm® Topical gel + Softgels

Vitiligo is characterized by a catalase deficiency that leads to the vacuolization of the melanocytes and keratinocytes.

VitiDerm® is an innovative product from DermoPro.

Oxidative stress and depigmentation

Due to oxidative stress (high concentrations of free radicals) vacuolization and cell death occur.

These include a gradual loss of melanocytes(1)(2)(3)(4) and an abnormally high level of hydrogen peroxide (H2O2) in the epidermis, leading to oxidative stress and oxidation of proteins and lipids.(5)

Keratinocytes in vitiligo lesions have proinflammatory responses, which can be inhibited through the combination of SOD and Catalase.

Concentration of hydrogen peroxide (H2O2) in vitiligo patients

 
Concentration of hydrogen peroxide (H2O2) in patients with vitiligo (red) compared to patients without vitiligo (blue)(9)

Numerous recent studies have pinpointed certain anomalies in patients with skin depigmentation.

In patients with vitiligo, it has been shown that a deficiency in catalase, vitamins and minerals is one of the causes of oxidative stress.(7) (12).

Oxidative stress damages the melanocyte membranes, the cells which are essential for skin pigmentation (6).

Cell damage in patients with vitiligo

Cell damage in vitiligo patients (red) and control subjects (blue) exposed to an increasing concentration of H2O2 (from 1-100 mM). Oxidative stress level and tyrosinase activity in vitiligo patients(8)

Write your review